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Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain
Xiaohui Zhang1,5, Liang Chen1,5, Biyun Zhu1,5, Liren Wang1, Caiyu Chen1, Mengjia Hong1, Yifan Huang 1, Huiying Li1, Honghui Han2, Bailian Cai3, Weishi Yu1,4, Shuming Yin1, Lei Yang1, Zuozhen Yang4, Meizhen Liu1, Ying Zhang1, Zhiyong Mao 3, Yuxuan Wu1, Mingyao Liu1 and Dali Li 1 ✉
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
腺嘌呤碱基编辑器；A•T-to-C•G
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
双碱基编辑器
Engineering a precise adenine base editor with minimal bystander editing
低旁观者效应的腺嘌呤碱基编辑器
实现小鼠体内高效编辑！
李大力团队开发基于IscB的高活性迷你基因编辑工具
Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing
Liang Chen 1,6, Biyun Zhu1,6, Gaomeng Ru1,6, Haowei Meng 2,6, Yongchang Yan2,6, Mengjia Hong1, Dan Zhang1, Changming Luan1, Shun Zhang1, Hao Wu2, Hongyi Gao1, Sijia Bai1, Changqing Li1, Ruoyi Ding1, Niannian Xue1, Zhixin Lei2, Yuting Chen3, Yuting Guan 1, Stefan Siwko4, Yiyun Cheng1, Gaojie Song 1, Liren Wang1, Chengqi Yi 2 , Mingyao Liu 1,5 and Dali Li 1